The Mountaineers got wins from Joe Carr at 157, Tom McMath at 165, Greg Jones at 174, Ryan Wilman at 184, Brent Miller at 197 and Ryan Kehler at heavyweight to put the Bobcats away and run their record to 10-2.
Catt's victory at 157 over Ryan Smith and McMath's win over Ton Y DeAnna were major decisions.
West Virginia's Shane Cunanan also collected a 10-5 win over Jon Spires.
The Mountaineers were coming off an emotional 32-2 win over rival Pitt on Friday.
Ohio drops to 10-10-1 on the season.
"We came out and looked pretty decent until West Virginia scored," said Ohio coach Joel Greenlee. "Then we said 'man they're as good as they said they were.' We had an opportunity to do some damage but we just didn't wrestle well."
The Mountaineers have won eight straight matches after suffering a 26-13 loss at nationally ranked Ohio State on Jan. 12. West Virginia returns to the mat next Saturday at Cleveland State for a 2 pm matchup before winding up the regular season on Sunday at Edinboro at 1 pm.
The EWL tournament will take place March 8-9.